Symbol Name ID |
Tyrobp
TYRO protein tyrosine kinase binding protein MGI:1277211 |
* | Aspects of the system are reported to show a normal phenotype. |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Acute leukemia |
Disease(s) Associated with TYROBP | |
Nasu-Hakola disease |
Mouse Phenotypes | immune system phenotype |
abnormal osteoclast differentiation |
increased B cell proliferation |
decreased T cell proliferation |
decreased uterine NK cell number |
abnormal myelopoiesis |
increased dendritic cell number |
increased germinal center B cell number |
abnormal microglial cell morphology |
abnormal osteoclast morphology |
increased spleen germinal center number |
increased spleen germinal center size |
increased IgG2a level |
increased IgG3 level |
impaired natural killer cell mediated cytotoxicity |
increased natural killer cell mediated cytotoxicity |
abnormal NK T cell physiology |
abnormal osteoclast physiology |
abnormal dendritic cell physiology |
decreased susceptibility to type IV hypersensitivity reaction |
decreased interferon-gamma secretion |
increased interleukin-6 secretion |
decreased susceptibility to experimental autoimmune encephalomyelitis |
decreased susceptibility to induced arthritis |
increased autoantibody level |
increased anti-double stranded DNA antibody level |
increased susceptibility to Herpesvirales infection |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||
Tyrobptm1.1Viv/Tyrobptm1.1Viv | ||||||||||||||||||||||||||||
Tyrobptm1Lll/Tyrobptm1Lll | * | ! | ||||||||||||||||||||||||||
Tyrobptm1Ttk/Tyrobptm1Ttk | ||||||||||||||||||||||||||||
Tyrobptm1Viv/Tyrobptm1Viv |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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